Selected Publications

Zhao TX, Sriranjan RS, Tuong ZK, Lu Y, Sage AP, Nus M, Hubsch A, Kaloyirou F, Vamvaka E, Helmy J, Kostapanos M, Jalaludeen N, Klatzmann D, Tedgui A, Rudd JHF, Horton SJ, Huntly BJP, Hoole SP, Bond SP, Clatworthy MR*, Cheriyan J*, Mallat Z*. NEJM Evidence. 2022; 1. *Corresponding authors. Link

Tuong ZK, Loudon KW, Berry B, Richoz N, Jones J, Tan X, Nguyen Q, George A, Hori S, Field S, Lynch AG, Kania K, Coupland P, Babbage A, Grenfell R, Barrett T, Warren AY, Gnanapragasam V, Massie C* & Clatworthy MR* (2021). Resolving the immune landscape of human prostate at a single-cell level in health and cancer. Cell Rep. 37. *Corresponding authors. Link

Stephenson E, Reynolds G, Botting RA, Calero-Nieto FJ, Morgan M, Tuong ZK, Bach K, Sungnak W, Worlock KB, Yoshida M, Kumasaka N, Kania K, Engelbert J, Olabi B, Spegarova JS, Wilson NK, Mende N, Jardine J, Gardner LCS, Goh I, Horsfall D, McGrath J, Webb S, Mather MW, Lindeboom RGH, Dann E, Huang N, Polanski K, Prigmore E, Gothe F, Scott J, Payne RP, Baker KF, Hanrath AT, Schim van der Loeff ICD, Barr AS, Sanchez-Gonzalez A, Bergamaschi L, Mescia F, Barnes JL, Kilich E, de Wilton A, Saigal A, Saleh A, Janes SM, Smith CM, Gopee N, Wilson C, Coupland P, Coxhead JM, Kiselev VY, van Dongen S, Bacardit J, King HW, Rostron AJ, Simpson AJ, Hambleton S, Laurenti E, Lyons PA, Meyer KB, Nikolic MZ, Duncan CJA, Smith K, Teichmann SA*, Clatworthy MR*, Marioni JC*, Gottgens B*, Haniffa M*. Single-cell multi-omics analysis of the immune response in COVID-19. Nat Med. 2021; 27:904-916. *Corresponding authors. Link

Fitzpatrick Z, Frazer G, Ferro A, Clare S, Bouladoux N, Ferdinand JR, Tuong ZK, Negro-Demontel ML, Suchanek O, Tajsic T, Harcourt K, Scott K, Bashford-Rogers R, Helmy A, Reich DS, Belkaid Y, Lawley T, McGavern DB*, Clatworthy MR*. Gut-educated IgA plasma cells defend meningeal venous sinuses. Nature. 2020; Nov; 587(7834):472-476. Link

Burrows N, Bashford-Rogers RJM, Bhute VJ, Peñalver A, Ferdinand JR, Stewart BJ, Smith JEG, Deobagkar-Lele M, Giudice G, Connor TM, Inaba A, Bergamaschi L, Smith S, Tran MGB, Petsalaki E, Lyons PA, Espeli M, Huntly BJP, Smith KGC, Cornall RJ, Clatworthy MR, Maxwell PH. Dynamic regulation of HIF-1 activity is essential for normal B cell development. Nat Immunol. 2020; 21:1408–1420. Link

Jing C, Castro-Dopico T, Richoz N, Tuong ZK, Ferdinand JR, Lok LSC, Loudon KW, Banham GD, Mathews RJ, Cader Z, Fitzpatrick S, Bashant KR, Kaplan MJ, Kaser A, Johnson RS, Murphy MP, Siegel RM, Clatworthy MR. Macrophage Metabolic Reprogramming Presents a Therapeutic Target in Lupus Nephritis. Proc Natl Acad Sci USA. 2020 Jun 15; 202000943. Link

Castro-Dopico T, Fleming A, Dennison TW, Ferdinand JR, Harcourt K, Stewart BJ, Cader Z, Tuong ZK, Jing C, Lok LSC, Mathews RJ, Portet A, Kaser A, Clare S, Clatworthy MR. GM-CSF calibrates macrophage defence and wound healing programmes during intestinal infection and inflammation. Cell Rep. 2020; 32:107857. Link

Bellomo A, Mondor I, Spinelli L, Lagueyrie M, Stewart BJ, Brouilly N, Malissen B, Clatworthy MR, Bajénoff M. Reticular Fibroblasts Expressing the Transcription Factor WT1 Define a Stromal Niche That Maintains and Replenishes Splenic Red Pulp Macrophages. Immunity. 2020 Jun 17;S1074-7613(20)30238-7. Link

Stewart BJ, Clatworthy MR. Applying single-cell technologies to clinical pathology: progress in nephropathology. J Pathol. 2020 Mar 3; doi: 10.1002/path.5417. PMID:32125696. Link

Park JE, Botting RA, Domínguez Conde C, Popescu DM, Lavaert M, Kunz DJ, Goh I, Stephenson E, Ragazzini R, Tuck E, Wilbrey-Clark A, Roberts K, Kedlian VR, Ferdinand JR, He X, Webb S, Maunder D, Vandamme N, Mahbubani KT, Polanski K, Mamanova L, Bolt L, Crossland D, de Rita F, Fuller A, Filby A, Reynolds G, Dixon D, Saeb-Parsy K, Lisgo S, Henderson D, Vento-Tormo R, Bayraktar OA, Barker RA, Meyer KB, Saeys Y, Bonfanti P, Behjati S, Clatworthy MR, Taghon T, Haniffa M, Teichmann SA. A cell atlas of human thymic development defines T cell repertoire formation. Science. 2020 Feb 21;367(6480). PMID:32079746. Link

James KR, Gomes T, Elmentaite R, Kumar N, Gulliver EL, King HW, Stares MD, Bareham BR, Ferdinand JR, Petrova VN, Polański K, Forster SC, Jarvis LB, Suchanek O, Howlett S, James LK, Jones JL, Meyer KB, Clatworthy MR, Saeb-Parsy K, Lawley TD, Teichmann SA. Distinct microbial and immune niches of the human colon. Nat Immunol. 2020; 21(3):343-353. PMID:32066951. Link

Stewart BJ, Ferdinand JR, Young MD, Mitchell TJ, Loudon KW, Riding AM, Richoz N, Frazer GL, Staniforth JU, Vieira Braga FA, Botting R, Popescu DM, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Polanski K, Efremova M, Green K, Velasco-Herrera M, Guzzo C, CollorD G, Mamanova L, Aho T, Armitage JN, Riddick AC, Mushtaq I, Farrell S, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Lindsay S, Bajenoff M, Warren AY, Stewart GD, Sebire N, Coleman N, Haniffa M*, Teichmann SA*, Behjati S*, Clatworthy MR*. Spatio-temporal immune zonation of the human kidney. Science. 2019;365(6460):1461-1466. Link

Stewart BJ, Ferdinand JR, Clatworthy MR. Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 2019 Dec 12. doi: 10.1038/s41581-019-0227-3. Link

Castro-Dopico T, Dennison TW, Ferdinand JR, Mathews RJ, Fleming A, Clift D, Stewart BJ, Jing C, Strongili K, Labzin LI, Monk EJM, Saeb-Parsy K, Bryant CE, Clare S, Parkes M, Clatworthy MR. Anti-commensal IgG drives intestinal inflammation and type 17 immunity. Immunity. 2019;50(4):1099-1114. Link

Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ, Ferdinand JR, Collord G, Botting RA, Popescu DM, Loudon KW, Vento-Tormo R, Stephenson E, Cagan A, Farndon SJ, Del Castillo Velasco-Herrera M, Guzzo C, Richoz N, Mamanova L, Aho T, Armitage JN, Riddick ACP, Mushtaq I, Farrell S, Rampling D, Nicholson J, Filby A, Burge J, Lisgo S, Maxwell PH, Lindsay S, Warren AY, Stewart GD, Sebire N, Coleman N, Haniffa M*, Teichmann SA*, Clatworthy MR*, Behjati S*. Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors. Science. 2018;361(6402):594-599. *Corresponding authors. Link

Banham GD, Flint SM, Torpey NP, Lyons PA, Shanahan DN, Gibson A, Watson CJE, O’Sullivan AM, ChadwickJA, Foster KE, Jones RB, Devey LR, Richards A, Erwig LP, Savage CO, Smith KGC, Henderson RB, Clatworthy MR. A phase 2 Experimental Medicine Randomised Placebo Controlled Trial of Belimumab in Kidney Transplantation (BEL114424). Lancet. 2018;391(10140):2619-2630. PMID: 29910042. Link

Berry MR, Mathews RJ, Ferdinand JR, Jing C, Loudon KW, Wlodek E, Dennison TW, Kuper C, Neuhofer W, Clatworthy MR. Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone. Cell. 2017; 170(5):860-74. Link

Clatworthy MR*, Petri Aronin C, Matthews RJ, Morgan NY, Smith KGC, Germain RN*. Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes. Nat Med. 2014; 20(12):1458-63. *Corresponding authors. Link

Clatworthy MR*, Harford S, Matthews RJ, Smith KGC*. FcgRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis. Proc Natl Acad Sci USA. 2014; 111(50):17971-6. *Corresponding authors. Link

Subramanian N, Natarajan K, Clatworthy MR, Wang Z, Germain RN. The adaptor MAVS promotes NLRP3 mitochondrial localization & inflammasome activation. Cell. 2013; 153:348-61. Link

Clatworthy MR*, Kettunen MI*, Hu D, Mathews RJ, Witney TH, Gallagher F, Jarvis L, Smith KG^, Brindle KM^. Hyperpolarised [1,4-13C2]fumarate allows early, non-invasive diagnosis of acute tubular necrosis. Proc Natl Acad Sci USA. 2012; 109(33):13374-9. Link

Clatworthy MR, Watson CJ, Plotnek G, Bardsley V, Chaudhry AN, Bradley JA, Smith KG. B-cell-depleting induction therapy and acute cellular rejection. N Engl J Med. 2009;360(25):2683-5. Link

Clatworthy MR, Willcocks L, Urban B, Langhorne J, Williams T, Peshu N, Watkins N, Floto RA, Smith KGC. SLE-associated defects in the inhibitory receptor FcgRIIb reduce susceptibility to malaria. Proc Natl Acad Sci USA. 2007; 104:7169-74. Link

Floto RA*, Clatworthy MR*, Heilbronn KR, Rosner DR, MacAry PA, Rankin A, Lehner PJ, Ouwehand WH, Allen JM, Watkins NJ and Smith KGC. Loss of function of a lupus-associated FcgRIIb polymorphism through exclusion from lipid rafts. Nature Medicine. 2005; 11:1056-8. *equal contribution. Link

Clatworthy MR and Smith KGC. FcgRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis. J Exp Med. 2004; 199:1-8. Link